Archive for November 11th, 2009

Oral malignant melanomas and benign lesions

Oral malignant melanomas:

Oral malignant melanomas really belong in a separate category. This type of tumor tends to respond in a similar way to radiation therapy as do late responding tissues. In such cases, when typical standard curative protocols are used to spare the late responding tissues, the tumor cells are also spared. [...]

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Palliative Radiation Therapy

Despite advanced technologies and extensive research, many cancers are still left without a definite cure. When cancer has a vast systemic dissemination, palliation becomes the main goal of therapy. Palliative radiotherapy treats local discomfort caused by either the primary tumor site or by enlarged metastatic lymph nodes. Approximately 50% of human [...]

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Periorbital, Auricular, Thyroid and Other Tumors

Periorbital and facial tumors:

Many types of tumors may occur in this area. Examples may include Lymphoma, Osteosarcoma, Mast cell tumor, Reticulum cell sarcoma, Fibrosarcoma, optic nerve Meningioma, Neurofribrosarcoma, Glial,Carcinomas, Undifferentiatedtumors, and others
Periorbital tumors may originate from either the surrounding soft tissues, or bone, or may result from extension [...]

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Radiotherapy for Intrathoracic and Abdominal Tumors

Intrathoracic tumors:
Long-term tumor control has been obtained with surgical resection of Thymomas. However, about 50% are not resectable. Although limited data is available, tumor remission has been reported following radiation therapy alone or combined with surgery (either before or after). When both modalities are used in combination, it is suggested [...]

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Radiotherapy for Bone, Joints and Spinal Tumors

Bone, joints and spinal tumors:
Osteosarcoma (OSA) is by far the most common primary bone tumor. Other primary bone tumors, such as Chondroma/chondrosarcoma, Hemangiosarcoma, Fibrosarcoma, and Multilobular osteochondrosarcoma (MLO, Chondroma rodens) may occur. A definitive diagnosis is not possible without a bone biopsy – but performing a biopsy risks causing [...]

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Radiotherapy For Oral Tumors

Oral tumors:
Maxillary, mandibular, lingual, tonsilar and salivary glands.
Aggressive surgical excision, whenever feasible, usually yields the highest survival times and tumor control. Adequate surgical margins are often difficult to achieve in the oral cavity, so adjuvant radiation therapy is required for residual disease. Radiation therapy is effective for incompletely [...]

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Radiotherapy For Brain and Nasal Tumors

Brain tumors:
(Meningiomas, pituitary macrotumors, other brain tumors and GME)
Meningiomas and pituitary tumors are generally more radioresponsive than other types of brain tumors.
The treatment of choice for Feline meningioma is surgery when feasible (depending on location). Radiation therapy is effective when surgical resection is not possible.
The treatment of choice [...]

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Radiotherapy For Tumor Control

Radiotherapy is a local cancer treatment modality and not meant to treat systemic disease. As previously mentioned, it is often combined with other adjuvant cancer treatment modalities, particularly chemotherapy and surgery. Covering every type of tumor is beyond the scope of this article. Below, is a table that generally illustrates which [...]

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Radiation Therapy Effect On Cells

Fractionation affects fast and slowly proliferating cells in different ways. This is summarized in the table below:

Table II – Effects of radiation dose fractionation on different cell types:

Tumor cells (fast proliferating)

Normal fast proliferating (Early responding tissues)

Normal slowly proliferating (Late responding tissues)

REPAIR
¯tumor control.

¯side effects and complications. ­tissue [...]

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Radiation Therapy Time, Dose and Fractionation

Time-dose and fractionation refers to the schedule of the radiation treatments to be administered. The graph above refers to the rate of tumor control and late complications (vertical axis) at a given total administered dose (horizontal axis). The probability of tumor control obviously increases with a higher total dose, but so does the probability of [...]

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